For a 75 kg male patient, morphine clearance is 1800 ml/min. After an oral administration dose, 4% o

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For a 75 kg male patient, morphine clearance is 1800 ml/min. After an oral administration dose, 4% of the drug is excreted unchanged in urine. The fraction of drug absorbed after an oral dose of morphine sulfate is 24% (F =0.24). If hepatic blood flow is 1500 ml/min, does morphine have any extra-hepatic metabolism? 

 
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